Figure 4.

Impact of Early Colonization on Age at First Respiratory Infection

(A) Microbiome profile group (MPG) transitions between healthy samples (T1) and the next sequenced infection (T2). Cell numbers indicate the number of times the respective transition from T1 to T2 was observed in the dataset; cells are colored to indicate the row proportions as per legend.

(B–D) Kaplan-Meier survival curves for age (days) of first (B) acute respiratory illness (ARI), (C) upper respiratory illness (URI), and (D) lower respiratory illness (LRI), stratified according to the MPG of the first healthy sample (collected by 9 weeks of age and prior to any infection, n = 160). Cox proportional hazards models were adjusted for age, gender, season, virus status in the early healthy sample, and virus status at the first event. Shaded areas indicate 95% confidence intervals.