Figure 2.

Mean longitudinal domain-specific cognitive changes from baseline associated with fluctuating and persistently elevated depressive symptoms versus no symptoms ^a

^a With adjustment for age, race/ethnicity, education, marital status, hysterectomy, current use of antidepressant medications, prior use of hormone therapy, smoking, use of cholesterol-lowering medication, alcohol use, body mass index, hypertension, prior cardiovascular/cerebrovascular disease including stroke or transient ischemic attack, diabetes, physical activity, mean length of follow-up time from baseline, and Women's Health Initiative hormone therapy trial treatment arm.