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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Cell Physiol. 2015 Jun;230(6):1170–1180. doi: 10.1002/jcp.24853

Fig. 3.

Fig. 3

Ligand-dependent LRP6 endocytosis. (A) Wnt induces caveolar endocytosis of LRP6, activating β-catenin pathway; whereas DKK1 shifts LRP6 away from rafts into the clathrin-dependent endocytotic and degradative pathway thereby inhibiting β-catenin pathway. Note that MVB is proposed to sequester the signalosome for sustained pathway activation. (B) DKK1 binds Kremen and LRP6 to induce internalization of the newly formed ternary complex, removing surface LRP6 hence inhibiting β-catenin signaling pathway.