Table 5.
SNPs with the strongest association signals from the GWAS analyses of BPI subjects.
| SNP | Chromosome | Base pair positiona | Closest genea,b | SNP location relative to genea | Minor Allele Frequency | P | Odds Ratio |
|---|---|---|---|---|---|---|---|
| Externalizing Group vs. Non-Externalizing Group | |||||||
| rs17099448 | 1 | 76921007 | ST6GALNAC3 | 51.79kb downstream | 0.025 | 2.56E-06 | 0.4633 |
| rs17622252 | 6 | 21439886 | CDKAL1 | 100.15kb downstream | 0.1333 | 4.39E-06 | 1.658 |
| rs2764655 | 1 | 76942171 | ST6GALNAC3 | 72.96kb downstream | 0.025 | 6.62E-06 | 0.4774 |
| rs10090419 | 8 | 124097812 | DERL1 | Intron | 0.175 | 1.94E-05 | 0.7077 |
| rs2071842 | 22 | 41313726 | POLDIP3 | Intron | 0.1667 | 2.16E-05 | 0.661 |
| rs2958709 | 8 | 106838246 | ZFPM2 | Intron | 0.1417 | 2.31E-05 | 0.6872 |
| rs2273238 | 6 | 90383081 | ANKRD6 | Coding region | 0.0417 | 2.33E-05 | 0.5065 |
| rs11015506 | 10 | 27409689 | ANKRD26 | Intron | 0.025 | 2.65E-05 | 3.33 |
| rs2997227 | 10 | 122575842 | WDR11 | 24.85kb upstream | 0.0778 | 2.98E-05 | 0.7426 |
| rs6461161 | 7 | 15239240 | TMEM195 | Intron | 0.3083 | 3.00E-05 | 1.327 |
| rs4869963 | 6 | 151341417 | MTHFD1L | Intron | 0.2833 | 3.48E-05 | 0.7507 |
| rs7913464 | 10 | 23551309 | PTF1A | 28.13kb downstream | 0.0583 | 3.76E-05 | 0.5527 |
| rs16851722 | 2 | 166741590 | SCN9A | 18.36kb downstream | 0.0583 | 4.40E-05 | 1.655 |
| rs333846 | 2 | 117695664 | - | - | 0.025 | 4.44E-05 | 4.72 |
| rs4341952 | 2 | 166728262 | SCN9A | 31.68kb downstream | 0.1917 | 4.47E-05 | 1.393 |
| rs1779518 | 14 | 40797200 | - | - | 0.3222 | 4.61E-05 | 1.424 |
| rs7739248 | 6 | 151323361 | MTHFD1L | Intron | 0.15 | 4.85E-05 | 0.7254 |
| rs11997383 | 8 | 40574573 | ZMAT4 | Intron | 0.1889 | 4.85E-05 | 0.618 |
| rs16831019 | 2 | 135259447 | ACMSD | 53.21kb upstream | 0.025 | 4.91E-05 | 0.4319 |
| rs11013397 | 10 | 23660815 | C10orf67 | Intron | 0.0667 | 5.10E-05 | 0.5823 |
| Early-Onset Subgroup vs. Non-Externalizing Group | |||||||
| rs9359856 | 6 | 90364704 | ANKRD6 | Intron | 0.2 | 4.52E-06 | 0.6091 |
| rs4761053 | 12 | 127072154 | - | - | 0.2583 | 6.95E-06 | 1.525 |
| rs6934804 | 6 | 90372739 | ANKRD6 | Intron | 0.1833 | 1.18E-05 | 0.6201 |
| rs1438108 | 20 | 1792858 | SIRPA | 29.96kb upstream | 0.0417 | 1.45E-05 | 0.4555 |
| rs1526303 | 2 | 174151593 | - | - | 0.3778 | 1.93E-05 | 0.7042 |
| rs1871946 | 2 | 213587652 | IKZF2 | Intron | 0.4407 | 2.24E-05 | 1.413 |
| rs2665452 | 7 | 97285019 | ASNS | 34.36kb downstream | 0.2333 | 2.39E-05 | 0.6398 |
| rs17622252 | 6 | 21439886 | CDKAL1 | 100.15kb downstream | 0.1333 | 2.71E-05 | 1.746 |
| rs13080973 | 3 | 140078740 | FOXL2 | 67.02kb downstream | 0.1583 | 2.89E-05 | 1.553 |
| rs12538214 | 7 | 154969302 | CNPY1 | 17.42kb downstream | 0.2167 | 2.91E-05 | 1.484 |
| rs2289439 | 15 | 87486790 | ABHD2 | Intron | 0.1083 | 3.15E-05 | 0.5478 |
| rs4726457 | 7 | 139269639 | TBXAS1 | Intron | 0.275 | 3.45E-05 | 0.6856 |
| rs2242400 | 12 | 24989341 | BCAT1 | Intron | 0.1167 | 3.48E-05 | 1.733 |
| rs742002 | 22 | 25765086 | - | - | 0.2917 | 4.14E-05 | 0.683 |
| rs4339696 | 9 | 4285880 | GLIS3 | Intron | 0.4333 | 4.27E-05 | 1.403 |
| rs2216316 | 7 | 53451934 | - | - | 0.1083 | 4.31E-05 | 1.539 |
| rs2530132 | 7 | 97286662 | ASNS | 32.72kb downstream | 0.2333 | 4.37E-05 | 0.6502 |
| rs10868082 | 9 | 85828929 | RMI1 | 20.12kb downstream | 0.1833 | 4.38E-05 | 0.6671 |
| rs17099448 | 1 | 76921007 | ST6GALNAC3 | 51.79kb downstream | 0.025 | 4.51E-05 | 0.3724 |
| rs1560651 | 5 | 167530850 | ODZ2 | Intron | 0.4833 | 4.59E-05 | 1.392 |
a
Genomic locations are based on NCBI Build 36.3.
b
Closest genes were genes in which the SNP was present or genes located within 200kb (kilobases) of the SNP.