Table 1.
Summary of EORTC QLQ-C30 functionality and symptom dimensions of QOL at baseline (primary efficacy population)—randomized phase
| QOL dimension | Trametinib (n = 178) |
Chemotherapy (n = 95) |
||||
|---|---|---|---|---|---|---|
| n | Mean | SD | n | Mean | SD | |
| Global health status/QOL | 175 | 63.3 | 21.6 | 88 | 68.7 | 20.9 |
| Physical functioning | 173 | 81.2 | 20.1 | 86 | 82.8 | 18.9 |
| Role functioning | 172 | 73.1 | 30.5 | 87 | 74.3 | 28.2 |
| Emotional functioning | 174 | 72.3 | 23.6 | 87 | 76.5 | 20.8 |
| Cognitive functioning | 175 | 88.3 | 17.4 | 89 | 90.6 | 17.2 |
| Social functioning | 175 | 75.5 | 29.0 | 89 | 78.3 | 25.4 |
| Fatigue | 172 | 32.6 | 26.6 | 89 | 28.8 | 24.8 |
| Nausea and vomiting | 175 | 10.2 | 18.7 | 89 | 8.6 | 16.7 |
| Pain | 173 | 28.8 | 30.0 | 88 | 28.6 | 26.0 |
| Dyspnea | 174 | 20.1 | 30.0 | 89 | 15.0 | 21.9 |
| Insomnia | 175 | 30.3 | 31.0 | 88 | 24.6 | 27.5 |
| Appetite loss | 174 | 19.5 | 29.8 | 89 | 16.1 | 26.2 |
| Constipation | 175 | 11.1 | 21.9 | 89 | 12.4 | 22.7 |
| Diarrhea | 175 | 7.6 | 16.9 | 89 | 6.4 | 14.1 |
EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire; QOL, quality of life; SD, standard deviation.
Values are rounded to one decimal place.