Table 3. Percentage increase (95% CI) of each adiposopathic marker for the selected life course model (n=1280).
| Age and sex only | +Smoking status | +Childhood SEP | +Adulthood SEP | Full model | |
|---|---|---|---|---|---|
| Accumulation model, relaxed a | |||||
| Adiponectin (years) | |||||
| 15 | 2.2 (−10.3, 16.4) | 0.7 (−11.6, 14.7) | 2.2 (−10.2, 16.4) | 2.3 (−10.3, 16.5) | 1.1 (−11.2, 15.2) |
| 36 | −6.3 (−13.9, 2.0) | −4.7 (−12.7, 4.0) | −6.0 (−13.7, 2.3) | −6.6 (−14.3, 1.8) | −4.6 (−12.7, 4.2) |
| 63 | −24.3 (−30.4, −17.7) | −26.1 (−32.2, −19.4) | −23.8 (−30.0, −17.2) | −24.2 (−30.3, −17.6) | −25.8 (−32.0, −19.1) |
| Leptin (years) | |||||
| 15 | 15.4 (1.5, 31.2) | 17.8 (3.3, 34.4) | 15.4 (1.5, 31.2) | 17.0 (2.9, 33.1) | 19.3 (4.6, 36.0) |
| 36 | 26.6 (16.4, 37.6) | 23.1 (12.6, 34.4) | 25.8 (15.7, 36.8) | 26.0 (15.8, 37.1) | 21.7 (11.3, 33.0) |
| 63 | 135.9 (117.2, 156.2) | 135.0 (115.4, 156.4) | 133.4 (114.8, 153.6) | 135.6 (117.0, 155.9) | 132.6 (113.1, 153.9) |
| CRP (years) | |||||
| 15 | 10.1 (−7.5, 31.0) | 10.3 (−7.7, 31.8) | 10.2 (−7.4, 31.1) | 12.6 (−5.4, 33.9) | 11.9 (−6.3, 33.7) |
| 36 | 14.4 (2.1, 28.1) | 13.9 (1.0, 28.4) | 13.1 (0.9, 26.6) | 13.9 (1.7, 27.7) | 13.1 (0.3, 27.6) |
| 63 | 37.0 (22.5, 53.1) | 39.1 (23.6, 56.5) | 34.3 (20.1, 50.3) | 35.5 (21.2, 51.4) | 36.1 (20.9, 53.3) |
| Interleukin-6 (years)b | |||||
| 15 | 16.4 (1.5, 33.6) | 19.1 (3.7, 36.8) | 16.5 (1.6, 33.7) | 18.3 (3.1, 35.7) | 20.9 (5.3, 38.9) |
| 36 | 11.1 (1.6, 21.5) | 8.9 (−0.8, 19.6) | 10.1 (0.7, 20.5) | 10.6 (1.1, 21.1) | 8.5 (−1.2, 19.1) |
| 63 | 20.1 (10.0, 31.2) | 20.7 (10.1, 32.3) | 18.5 (8.4, 29.5) | 19.5 (9.4, 30.5) | 19.5 (9.0, 31.1) |
| Early old age sensitive period model (60–64 years only)c | |||||
| Adiponectin | −30.1 (−37.8, −22.3) | −32.0 (−39.9, −24.1) | −29.5 (−37.3, −21.7) | −29.8 (−37.6, −22.0) | −29.8 (−37.8, −21.8) |
| E-selectin | 16.2 (10.2, 22.5) | 17.5 (11.1, 24.2) | 15.4 (9.4, 21.8) | 16.1 (10.0, 22.4) | 16.6 (10.1, 23.4) |
| Tissue plasminogen activator | 34.3 (25.2, 44.0) | 31.3 (21.9, 41.3) | 33.9 (24.7, 43.7) | 34.2 (25.1, 44.0) | 30.9 (21.4, 41.1) |
Abbreviations: CI, confidence interval; CRP, C-reactive protein; IL-6, interleukin-6; SEP, socioeconomic position.
a
Overweight compared with non-overweight at 15, 36 or 60–64 years, adjusted for overweight status for the other 2 years.
b
The ‘strict' accumulation model was chosen as the best fitting life course model for IL-6, but P-values were similar to the ‘relaxed' accumulation model, so we have shown the latter model here to compare coefficients for overweight at each age with the other inflammatory marker.
c
Overweight compared with non-overweight at age 60–64 years.