Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Neurovirol. 2015 Feb 26;21(3):310–321. doi: 10.1007/s13365-014-0308-9

Figure 1. Nuclease-induced double strand breaks (DSBs) initiate the cellular homologous recombination (HR) and non-homologous end joining (NHEJ) DNA repair pathways exploited by the ZFN, TALEN, and CRISPR genome editing technologies.

Figure 1

Yellow squares indicate target genome. PAM, protospacer adjacent motif. Indel, insertion or deletion mutants.