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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Mar 24;1855(2):248–253. doi: 10.1016/j.bbcan.2015.03.004

Figure 1. Matrix stiffness reduces HOXA9 expression.

Figure 1

Recent work from Mouw et al. [10] shows that (a) culturing human mammary epithelial cells on stiff polyacrylamide gels decreases HOXA9 expression in vitro and (b) treatment of MMTV-PyMT mice with a LOX inhibitor (LOX-i) reduces tissue fibrosis and matrix stiffening in vivo, restores HOXA9 expression to wild-type (WT) levels and impedes tumor progression.