Figure 2.
Downregulation of GRP78 expression accompanies aging in the rat SNc. Nigral tissue extracts from young (2 month) and old (24 month) rats were western blotted with GRP78, TH, α-syn and GAPDH antibodies (see Supplementary Figure 1A). The amount of analyzed proteins was normalized to GAPDH and shown on graphs in arbitrary units (a.u.). One tailed unpaired t test. Data are presented as mean ± SE (*P<0.05, **P<0.01; N=4 young females; 5 all other groups).