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. Author manuscript; available in PMC: 2016 May 22.
Published in final edited form as: FEBS Lett. 2015 Apr 29;589(12):1340–1345. doi: 10.1016/j.febslet.2015.04.029

Figure 1. Inhibition of PI3K signaling decreased junctional conductance mediated by Cx50 but not Cx46.

Figure 1

(A) Gap junctional conductance between HeLa cell pairs expressing Cx50 treated with an inhibitor of the p110α catalytic subunit of PI3K (PIK-75), Akt inhibitor VIII (Akti), or the vehicle (DMSO). Cell pairs expressing Cx50 showed a three-fold decrease in gap junctional coupling after treatment with either PIK-75, or Akti. Treatment with vehicle (DMSO) had no effect. (B) HeLa cells transiently transfected with Cx46 and treated with PIK-75 showed no significant difference in gap junctional coupling compared to controls. Data are the mean ± SE.