Skip to main content
. Author manuscript; available in PMC: 2016 May 22.
Published in final edited form as: FEBS Lett. 2015 Apr 29;589(12):1340–1345. doi: 10.1016/j.febslet.2015.04.029

Figure 3. Activation of PI3K signaling specifically increased junctional conductance mediated by Cx50.

Figure 3

PI3K signaling was stimulated by co-expression of the constitutively active catalytic subunit p110αH1047R (caPI3K) in paired Xenopus oocytes expressing either Cx50 or Cx46. (A) Gap junctional conductance of pairs co-expressing Cx50 and caPI3K showed increased gap junctional conductance compared to pairs expressing Cx50 alone. Cells injected with water or caPI3K alone had negligible junctional conductance. (B) Xenopus oocyte pairs co-expressing Cx46 and caPI3K showed no significant difference in coupling compared to pairs with Cx46 alone. Data are the mean ± SE.