Fig. 1.
Effects of early postnatal treatment with the VPAC2 receptor agonist Ro 25-1553 on PSD-95 (a) and synaptophysin (b) levels one week later in the hippocampus and prefrontal cortex. Mice were injected s.c. once daily with phosphate-buffered saline (PBS) or Ro 25-1553 (0.07 nmol/g) during P1-14. One week after the last injection, the hippocampus and prefrontal cortex were dissected, and then PSD-95 and synaptophysin (SYN) expression was analyzed by Western Blot. Expression levels were normalized to β-actin and are presented as fold change relative to control PBS results. The results are expressed as the mean ± SEM of 3 mice/group. *P < 0.05 compared with the PBS-treated group.