Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neurobiol Aging. 2015 Feb 27;36(6):2201–2212. doi: 10.1016/j.neurobiolaging.2015.02.012

Figure 4. E50K optineurin is associated with a higher number of damaged axons.

Figure 4

(A) Paraphenylenediamine (PPD) staining in representative optic nerve cross sections from wildtype (WT) and BAC hOPTNE50K (E50K) mice. PPD stains the axoplasm of damaged or dead axons (arrows). Scale bar, 10 μm. (B) Axon counts of healthy axons showed no significant difference between the two genotypes (p = 0.33). However, there was a higher number of damaged or degenerated axons by PPD staining (* p = 0.03) in BAC hOPTNE50K mice (n = 4 animals, 8 optic nerves) than wildtype littermates (n = 6 animals, 11 optic nerves). Data represent means ± SEM.