TABLE 3.

DTI-Manual ROI-based results comparing Preterm CHDs with High Risk Term Non-CHD and Preterm Non-CHD Comparison Groups

		Preterm	Term	Preterm CHD
		n=27 mean (SD)	n=28 mean (SD)	n=21 mean (SD)	p *
Peripheral White Matter
Parietal**	FA	.17 (.06)	.18 (.05)	.17 (.06)	.948
	RA	.14 (.05)	.15 (.04)	.14 (.06)	.953
	Axial	1.95 (.33)	1.80 (.35)	1.91 (.40)	.378
	Radial	1.52 (.33)	1.39 (.31)	1.49 (.38)	.492
	ADC	1.67 (.33)	1.53 (.32)	1.63 (.38)	.475
Optic	FA	.32 (.05)	.34 (.06)	.29 (.08)	# .045
Radiation**	RA	.27 (.04)	.29 (.05)	.25 (.07)	# .032
	Axial	2.07 (.32)	1.95 (.34)	2.05 (.32)	.387
	Radial	1.26 (.24)	1.15 (.24)	1.30 (.26)	.162
	ADC	1.53 (.26)	1.41 (.26)	1.54 (.26)	.243
Deep White Matter
Splenium	FA	.54 (.09)	.59 (.07)	.46 (.12)	##.00001
	RA	.50 (.10)	.57 (.08)	.42 (.13)	##.00003
	Axial	2.32 (.34)	2.20 (.34)	2.23 (.35)	.615
	Radial	.91 (.20)	.77 (.17)	1.02 (.22)	##.00008
	ADC	1.38 (.22)	1.24 (.21)	1.42 (.21)	#.012
Gray Matter
Thalamus**	FA	.17 (.02)	.17 (.02)	.16 (.03)	.716
	RA	.14 (.02)	.14 (.02)	.14 (.02)	.624
	Axial	1.36 (.20)	1.23 (.19)	1.34 (.21)	#.042
	Radial	1.07 (.16)	.98 (.16)	1.07 (.18)	.066
	ADC	1.17 (.17)	1.07 (.18)	1.16 (.19)	.063

^*ANOVA

^**Measurements are average of L and R readings

p-value ≤ 0.05 significant

Tukey’s Pairwise Comparisons:

^#Term controls significantly different from CHD’s. 2 other pairwise comparisons (term controls vs. preterm controls, preterm controls vs. CHD’s) non-significant

^##CHD’s significantly different from both preterm and term controls. Pairwise comparison of preterm and term controls non-significant