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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Dec 30;232(12):2169–2179. doi: 10.1007/s00213-014-3845-2

Fig. 2.

Fig. 2

Physiological and behavioral responses to forced methamphetamine consumption and abstinence. (a) Mean (± SEM) daily methamphetamine intake during the 2-week period of forced methamphetamine consumption prior to abstinence, showing escalation of intake. (b) Mean (± SEM) body weights, measured every 3-4 days over the course of the 6-week long experiment. n = 8 animals/group. (c) Mean (± SEM) overall withdrawal signs, recorded every 12h for 72h following removal of methamphetamine bottles. * p < 0.05, ** p < 0.01, *** p < 0.001, indicate significant differences between methamphetamine pre-exposed and not-pre-exposed groups.