Mean (± SEM) percent change in daily mg/kg methamphetamine consumption from not pre-exposed, no-shift controls on day 1 (a), days 1-7 (b), and days 8-14 (c) of two-bottle choice testing. Not pre-exposed, no-shift control level is set at 0. * p < 0.05 in (b) indicates a significant difference from not pre-exposed no-shift and not pre-exposed shift groups. * p < 0.05, ** p < 0.01, *** p < 0.001. n = 8 animals/group.