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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: Cancer Res. 2015 Mar 13;75(10):1972–1982. doi: 10.1158/0008-5472.CAN-14-2761

Figure 5. WNT5A inhibits tumor multiplicity and metastasis in ErbB2-induced mammary cancer.

Figure 5

MMTV-ErbB2 transgenic mice were crossed with WNT5A+/− to produce ErbB2/WT and ErbB2/WNT5A+/− mice. Tumor onset days (A), multiplicity (B), as well as lung metastasis assessed by hematoxylin & eosin staining of paraffin-embedded lung sections (representative images in C and summarized in D) were assessed. % in C indicates the percentage of animals with lung metastasis. Numbers of metastatic nodules were plotted and P values indicated. A. n=6 for ErbB2/WT and n=16 for ErbB2/WNT5A+/−; B, D: n=6 for each group.