Table 1.

miRNAs regulating BTICs in gliomas and GBM stem cells.

MicroRNAs	Targets	Expression in GSCs	Reference
Adult patients
miR-128	RTKs, EGFR, PDGFR, Akt, Bmi1, HIF-1, VEGF, E2F3	Downregulated	[54, 59–62]
miR-181a, b, c	Bcl-2,	Downregulated	[54, 184]
miR-125b	CDK6, CDC25A, E2F2, MMP-2, MMP-9, RECK, TIMP3	Downregulated	[56–58]
miR-143	N-RAS, PI3K/Akt, MAPK/ERK	Downregulated	[57, 63, 185]
miR-153	Bcl-2, Mcl-1	Downregulated	[64, 186]
miR-7	EGFR, Akt	Downregulated	[65]
miR-145	ABCG2	Downregulated	[66]
miR-34a	Akt, Wnt pathway, c-Met, Notch-1, Notch-2	Downregulated	[66, 67, 69]
miR-34c-3p, 5p	Notch-2	Downregulated	[70]
miR-146a	Notch-1	Downregulated	[71]
miR-326	Notch-1, Notch-2, PKM2	Downregulated	[73]
miR-107	Notch-2, MMP-12	Downregulated	[72]
miR-622	ATF2	Downregulated	[74]
miR-152	KLF4	Downregulated	[75]
miR-218	Bmi1	Downregulated	[76]
miR-124	SNAI2, CDK6	Downregulated	[17, 77, 78]
miR-137	RTVP-1, c-KIT, YBX1, Akt2, CDC42, CDK6, TGFβ2	Downregulated	[77, 79, 80]
miR-451	PI3K/Akt pathway	Downregulated	[81, 82]
miR-200 family	CREB1, RAB family, SIM2-s	Downregulated	[83–86]
miR-221, miR-222	p27 and p57	Upregulated	[54, 187]
miR-21	FASLG, FOXO1, IGFBP3, FBXO11	Upregulated	[55, 188–191]
miR-10 family	CUB, SUSHI	Upregulated	[87, 88]
miR-17-92 cluster	CTGF, PTEN	Upregulated	[91, 92]
miR-9	CAMTA1	Upregulated	[90]
miR-300	SH3GL2	Upregulated	[95]
miR-582-5p	Caspase3, caspase9, Bim	Upregulated	[94]
miR-363	Caspase3, caspase9, Bim	Upregulated	[94]
miR-1275	Claudin11	Upregulated	[96]
Pediatric patients
miR-129	Undefined	Downregulated	[99]
miR-142-5p	Undefined	Upregulated	[99]
miR-25	P57	Upregulated	[99, 192]
miR-17-92	PTEN, RB1	Upregulated	[92]