Table 4.
Genotype and allele frequencies of polymorphisms in the TNFRSF11B (OPG) gene in rheumatoid arthritis (RA) patients with normal and low bone mineral density (BMD).
| SNP | Genotypes | RA with normal BMD | RA with low BMD | Allele | RA with normal BMD | RA with low BMD | P | OR |
|---|---|---|---|---|---|---|---|---|
| (95% CI) | ||||||||
| C950T rs2073617 |
CC | 9 (50.0) | 16 (44.4) | C | 25 (69.4) | 46 (63.9) | 0.67 | 1.3 (0.55–3.03) |
| CT | 7 (38.9) | 14 (38.9) | T | 11 (30.6) | 26 (36.1) | |||
| TT | 2 (11.1) | 6 (16.7) | ||||||
|
| ||||||||
| C209T rs3134070 |
CC | 17 (81.0) | 29 (69.0) | C | 37 (88.1) | 70 (83.3) | 0.60 | 1.5 (0.49–4.43) |
| CT | 3 (14.3) | 12 (28.6) | T | 5 (11.9) | 14 (16.7) | |||
| TT | 1 (4.8) | 1 (2.4) | ||||||
|
| ||||||||
| T245G rs3134069 |
AA | 20 (90.9) | 39 (88.6) | A | 42 (95.5) | 82 (93.2) | 0.72 | 1.5 (0.29–7.95) |
| AC | 2 (9.1) | 4 (9.1) | C | 2 (4.5) | 6 (6.8) | |||
| CC | 0 (0) | 1 (2.3) | ||||||
OPG: osteoprotegerin, SNP: single nucleotide polymorphism, RA: rheumatoid arthritis, BMD: bone mineral density, OR: odds ratios, and 95% CI: 95% confidence intervals. In order to compute OR (95% CI) the following alleles were used as reference: in correspondence with the allele of risk: rs2073617 T, rs3134070 T, and rs3134069 C.