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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Clin Cancer Res. 2015 Mar 5;21(10):2297–2304. doi: 10.1158/1078-0432.CCR-14-3258

Figure 1.

Figure 1

Renal toxicity in a first-in-human phase I study using JNJ-38877605. A) Serum creatinine levels as collected from each individual in the 60mg JNJ-38877605 over time were plotted. Each line represents an individual patient. B) Calculated creatinine clearance as determined by the Cockroft-Gould formula at each time-point is plotted. Each line represents an individual patient. C) Human pharmacokinetics of JNJ-38877605 after oral administration on cycle 1 day 1 of the different patient cohorts. Each line represents the mean concentration over time for a dosing cohort.