Table 2. Metabolites of JNJ-38877605 in Plasma.
| Species | Metabolites | UD | |||||||
|---|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | M6 | M7 | M10 | ||
| Rat | 136 | 64 | 57 | 15 | 6 | 1466 | |||
| Dog | 31 | 55 | 40 | 575 | |||||
| Rabbit | 6388 | 778 | 603 | 2259 | 1780 | 395 | 822 | 22836 | |
| Man | 3 | 387 | 208 | 2 | 111 | ||||
The metabolites of JNJ-38877605 were determined in urine/faeces of rat, dog and rabbit and in urine of man. Animals were dosed with 3H-JNJ-38877605 at 2.5 mg/kg in rat, 2.5 mg/kg in dog and 100 mg/kg in rabbit. Humans were dosed at 60 mg. JNJ-38877605 and its metabolites in plasma were expressed as ngeq/ml. Metabolites were measured at about Cmax ranging between 1 and 4h depending on the species. UD=unchanged drug or JNJ-38877605