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. 2012 Jul 20;3(2):111–125. doi: 10.1002/jrsm.1045

Table 5.

REML estimation of thrombolytic drugs data: Wald χ2 statistics testing consistency, selected estimated treatment effects and their standard errors, comparing standard approach with data augmentation approach for various choices of h and m and the reference treatment

Data augmentation approach

Standard approach Reference treatment m 0.08 0.5


h 0.001 0.01 0.1 0.001 0.01 0.1
Wald test of consistency Inline graphic 8.61 A 8.61 8.61 8.60 8.60 8.59 8.42
B 8.61 8.61 8.62 8.61 8.62 8.64
C 8.61 8.61 8.60 8.60 8.59 8.35
Treatment effect δAB −0.161 A −0.161 −0.161 −0.161 −0.161 −0.161 −0.162
B −0.161 −0.161 −0.161 −0.161 −0.161 −0.158
C −0.161 −0.161 −0.161 −0.161 −0.161 −0.162
Treatment effect δAG −0.197 A −0.197 −0.197 −0.197 −0.197 −0.198 −0.205
B −0.197 −0.197 −0.198 −0.197 −0.198 −0.202
C −0.197 −0.197 −0.197 −0.197 −0.198 −0.202
Standard error se(δAB) 0.046 A 0.046 0.046 0.046 0.046 0.046 0.046
B 0.046 0.046 0.046 0.046 0.046 0.046
C 0.046 0.046 0.046 0.046 0.046 0.047
Standard error se(δAG) 0.222 A 0.222 0.222 0.222 0.222 0.222 0.221
B 0.222 0.222 0.222 0.222 0.222 0.221
C 0.222 0.222 0.222 0.222 0.222 0.221