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HDAC inhibition of folate based hydroxamates (IC50 in nM) against selected HDAC isoforms.
| ||||
|---|---|---|---|---|
| n | HDAC 1 | HDAC 6 | HDAC 8 | |
| 15a | (1) | NI | 8050 ± 330 | 40 ± 5% |
| 15b | (4) | 1770 ± 100 | 132 ± 23 | 2390 ± 640 |
| 15c | (5) | 1800 ± 180 | 193 ± 41 | 2370 ± 430 |
| 15d | (6) | 2760 ± 550 | 179 ± 19 | 1560 ± 340 |
| SAHA | - | 38 ± 2 | 144 ± 23 | 232 ± 19 |
% inhibition at 10 μM are given if the IC50 was above 10 μM.
NI: No significant inhibition (below 20% Inhibition at 10 μM concentration).
