Skip to main content
. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: Eur J Med Chem. 2015 Apr 8;96:340–359. doi: 10.1016/j.ejmech.2015.04.014

Table 5.

Folate receptor-dependent anti-proliferative activity of folate- and pteroate-derived hydroxamates (IC50 in μM).

graphic file with name nihms679202u5.jpg
R n KB HeLa A549
graphic file with name nihms679202t1.jpg 11a 1 NI NI NT
11b 2 NI NI NT
11c 3 25 ± 2%† NI NT
11d 4 53.7 ± 2.4 34 ± 3%† NI
11e 5 30.3 ± 2.1 56.6 ± 1.1 NI
11f 6 33 ± 3%† 35 ± 3%† NT
11g 7 47 ± 3%† 36 ± 8%† NT
graphic file with name nihms679202t2.jpg 15a 1 NT NT NT
15b 4 NI NI NT
15c 5 NI NI NT
15d 6 NT NT NT
SAHA - 1.8 ± 0.3 3.7 ± 0.2 NT

NI: No inhibition (below 20% inhibition at 100 μM);

†

: % inhibition at 100μM;

NT: Not tested.