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. Author manuscript; available in PMC: 2016 Jun 19.
Published in final edited form as: J Mol Biol. 2015 Apr 11;427(12):2220–2228. doi: 10.1016/j.jmb.2015.04.002

Figure 1. The reaction and structure of IspG.

Figure 1

(a) IspG converts 2-C-methyl-D-erythritol-2,4-cyclo-diphosphate (MEcPP, 1) to (E)-1-hydroxy-2-methylbut-2-enyl-4-diphosphate (HMBPP, 2) under consumption of two electrons and two protons. (b) The enzyme forms head to tail homodimers which can alternate between an open and closed conformation through a 64° rotation of the C-terminal domain.