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. Author manuscript; available in PMC: 2016 Jun 19.
Published in final edited form as: J Mol Biol. 2015 Apr 11;427(12):2220–2228. doi: 10.1016/j.jmb.2015.04.002

Figure 3. Proposed reaction mechanism for the IspG catalyzed conversion of MEcPP to HMBPP.

Figure 3

Structures observed crystallographically are labelled with black-framed characters. Grey labels for the short-lived reaction intermediates c1/c2 (in brackets) indicate availability of structural data from a different substrate, i.e. the epoxide analogue 5. Proposed oxidation and EPR spin states of the [Fe4S4] cluster are shown where available. EPR results from freeze-quenched solutions indicate that the ferraoxetane structure d3 is in equilibrium with d1/d2. IET = internal electron transfer.