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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Immunol. 2015 Apr 27;194(11):5446–5454. doi: 10.4049/jimmunol.1403012

Figure 2.

Figure 2

Modulation of C5 Signal Transduction in CAIA. Anti-C5 mAb, commercially available C5 and C5aR1 siRNAs affected the Clinical Disease Activity (CDA) in CAIA. CAIA was induced in WT mice as mentioned in the Materials and Methods. A. CAIA mice were injected with 750 ug of either IgG1 or anti-C5 antibody (BB5.1) on day 3 and at day 7. Data represent the mean CDA ± SEM (n = 5) *p < 0.05. B-D. Knockdown using C5siRNA and/or C5aRsiRNA. CAIA was induced as described. Groups (n = 5) were injected i.v. day -5, day 0 and at day 3 either with Scrambled siRNA, C5siRNA C5aR siRNA, or the combination of C5 and C5aR siRNAs. B) CDA, C) Prevalence, D) mice weights. All data represent the mean CDA ± SEM *p < 0.05 in comparison to scrambled siRNA injected mice