Table 1. HLA-B*42:01 associations with IFNγOLP responses (n=1,009).
| Protein-OLP | Sequence OLP | Optimal | Epitope | HXB2 | Q-valued | Reference |
|---|---|---|---|---|---|---|
| Gag-3 | EKIRLRPGGKKHYMLKHL | RPGGKKHYMa | Gag-RM9 | Gag(22-30) | ns | This study |
| Gag-20 | QMVHQAISPRTLNAWVKV | SPRTLNAWVb | Gag-SV9 | Gag(148-156) | ns | This study |
| Gag-25 | GATPQDLNTMLNTVGGH | TPQDLNTML | Gag-TL9 | Gag(180-188) | 1.28E-124 | Llano 2008 |
| Gag-37 | WIILGLNKIVRMYSPVSIc | no | no | no | 1.28E-02 | This study |
| Gag-48 | ACQGVGGPSHKARVLAEA | GPSHKARVL | Gag-GL9 | Gag(355-363) | ns | Llano 2008 |
| Gag-52 | QRSNFKGPKRIVKCF | GPKRIVKCFb | Gag-GF9 | Gag(386-394) | 8.25E-03 | This study |
| RT-184 | PSINNETPGIRYQYNVL | TPGIRYQYNVLb | RT-TL11 | Pol(294-304) | 2.01E-12 | This study |
| RT-186 | QYNVLPQGWKGSPAIF | LPQGWKGSPAIb | RT-LI11 | Pol(304-314) | 3.90E-02 | This study |
| RT-187 | QGWKGSPAIFQSSMTKIL | SPAIFQSSMb | RT-SM9 | Pol(311-319) | ns | This study |
| RT-202 | SKLNWASQIYPGIKVRQL | YPGIKVRQL | RT-YL9 | Pol(426-434) | 7.17E-09 | Llano 2008 |
| Int-244 | MASEFNLPPIVAKEIVA | LPPIVAKEI | Int-LI9 | Pol(743-751) | 5.04E-49 | Llano 2008 |
| Int-275 | KVVPRRKAKIIKDYGKQM | IIKDYGKQMa | Int-IM9 | Pol(982-990) | 1.48E-98 | This study |
| Nef-73 | GALTSSNTDTTNADCAWLc | no | no | no | 3.45E-02 | This study |
| Nef-76 | EVGFPVRPQVPLRPMTFK | RPQVPLRPM | Nef-RM9 | Nef(71-79) | 8.24E-17 | Llano 2008 |
| Nef-78 | FKGAFDLSFFLKEKGGLc | no | no | no | 9.15E-03 | This study |
| Nef-84 | NYTPGPGVRYPLTFGWCF | TPGPGVRYPL | Nef-TL10 | Nef(382-411) | 3.26E-16 | Llano 2008 |
| Vpr-281 | ELKQEAVRHFPRPWLHGL | FPRPWLHGL | Vpr-FL9 | Vpr(34-42) | 1.61E-70 | Llano 2008 |
| Vif-407 | RHHYESRHPKVSSEVHI | HPKVSSEVHIa | Vif-HI10 | Vif(48-57) | 7.97E-69 | This study |
| Env-328 | VCTRPNNNTRKSIRI | RPNNNTRKSIb | Env-RI10 | Env(298-307) | 2.24E-03 | This study |
| Env-401 | NIPRRIRQGFEAALL | IPRRIRQGFa | Env-IF9 | Env(843-851) | ns | This study |
a
New optimal epitope (not listed in Los Alamos ‘A’ List Database) defined in this study.
b
New optimal epitope (not listed in Los Alamos ‘A’ List Database) not defined in this study.
c
Optimal epitope not identified within the OLP sequence.
d
q-values for associations between HLA-B*42:01 expression (n=181) and OLP responses computed from analysis of IFNγ ELISpot data across 1,009 subjects. no, not optimized; ns, not significant.