Table 2.
HLA-B*42:01-associated HIV-1 polymorphisms.
| Protein | HXB2 location | Escape variantselecteda | Sequenceb | % B*42:01+ | % B*42:01- | P | Qc | N |
|---|---|---|---|---|---|---|---|---|
| Gag-p17 | 20 | S | IRLRPGGKKHYMLKH | 5 | 2 | 6.8E-03 | 4.6E-02 | 1767 |
| 28 | Q | IRLRPGGKKHYMLKH | 29 | 13 | 8.0E-12 | 2.9E-10 | 1765 | |
| 28 | S | IRLRPGGKKHYMLKH | 6 | 2 | 8.8E-05 | 8.7E-04 | 1765 | |
| 28 | R | IRLRPGGKKHYMLKH | 22 | 13 | 2.3E-04 | 1.9E-03 | 1765 | |
| 30 | R | IRLRPGGKKHYMLKH | 25 | 12 | 9.8E-10 | 2.7E-08 | 1765 | |
| 30 | K | IRLRPGGKKHYMLKH | 14 | 7 | 1.0E-04 | 9.2E-04 | 1765 | |
| Gag-p24 | 182 | T | EGATPQDLNTMLNTV | 9 | 1 | 2.6E-08 | 5.8E-07 | 1857 |
| 386 | S | NFKGPKRIVKCFNCG | 46 | 29 | 6.4E-06 | 8.8E-05 | 1122 | |
| 387 | R | NFKGPKRIVKCFNCG | 43 | 34 | 2.6E-03 | 1.9E-02 | 1131 | |
| Pol-RT | 427 | S | SQIYPGIKVRQLCKL | 24 | 5 | 2.5E-15 | 4.8E-14 | 1052 |
| 427 | A | SQIYPGIKVRQLCKL | 31 | 11 | 8.5E-12 | 7.1E-11 | 1052 | |
| 427 | Q | SQIYPGIKVRQLCKL | 4 | 1 | 2.4E-03 | 9.4E-03 | 1052 | |
| 429 | V | SQIYPGIKVRQLCKL | 10 | 1 | 5.8E-10 | 3.9E-09 | 1051 | |
| 433 | N | SQIYPGIKVRQLCKL | 5 | 2 | 9.8E-03 | 3.1E-02 | 1049 | |
| 436 | R | SQIYPGIKVRQLCKL | 18 | 7 | 2.3E-05 | 1.2E-04 | 1049 | |
| Pol-Int | 746 | V | EFNLPPIVAKEIVAS | 51 | 17 | 5.9E-13 | 6.3E-12 | 565 |
| 749 | R | EFNLPPIVAKEIVAS | 28 | 2 | 6.8E-17 | 1.7E-15 | 565 | |
| 984 | R | KVKIIKDYGKQMAGA | 79 | 41 | 8.7E-15 | 1.1E-13 | 562 | |
| 985 | E | KVKIIKDYGKQMAGA | 7 | 1 | 1.6E-03 | 6.7E-03 | 562 | |
| 990 | V | KVKIIKDYGKQMAGA | 7 | 1 | 1.3E-03 | 5.6E-03 | 562 | |
| Vpr | 42 | I | VRHFPRPWLHSLGQY | 12 | 3 | 1.1E-02 | 3.2E-02 | 255 |
| 45 | H | VRHFPRPWLHSLGQY | 61 | 42 | 5.6E-03 | 2.2E-02 | 254 | |
| Vif | 48 | N | ESRHPKVSSEVHIPLG | 32 | 9 | 4.7E-05 | 7.5E-04 | 255 |
| Env | 843 | V | IRNIPRRIRQGFEAA | 17 | 4 | 2.0E-03 | 2.0E-02 | 248 |
| 845 | T | IRNIPRRIRQGFEAA | 41 | 22 | 1.1E-03 | 1.9E-02 | 245 |
a
Escape polymorphism shows the amino acid selected in that particular HXB2 location, also indicated by bold face.
b
Optimal epitope is underlined with the consensus sequence shown for +/- 3 amino acids; bold face indicates the site of polymorphism.
c
Only q values <0.05 are included.