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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Biomed Mater Res B Appl Biomater. 2014 Nov 17;103(7):1390–1401. doi: 10.1002/jbm.b.33322

Figure 1.

Figure 1

Schematic representation of the structure of spider silk penta-block polymer. (a) Spider silk core sequence; (b) cell specific peptides and payload sequences; (c) cell-penetrating peptide and nuclear localization sequences used in the study; (d) recombinant DNA strategy used to prepare the spider silk gene delivery systems for the study. NcoI, NheI, SpeI, XhoI are restriction enzymes (RE). A box above/below a specific RE indicates an oligonucleotide sequence recognized by this RE. Pet30a(+) plasmid is in blue, cloning linker is in yellow, spider silk monomer is in dark blue, poly-L-lysine sequence is in magenta, HAB peptide is in orange and NLS is in green.