Table 1.
Effect of 8-week-lasting high-fructose intake on some cardiovascular and metabolic parameters in control and L-NAME treated Wistar rats.
| Wistar | Wistar + fructose | Wistar + L-N | Wistar + L-N+ fructose | |
|---|---|---|---|---|
| BP (mmHg) | 118.1±2.0 | 124.6±1.6 * | 151.2±4.4 ††† | 155.6±6.4 |
| HR (bpm) | 402.3±6.1 | 392.2±9.9 | 402.6±13.0 | 406.6±11.6 |
| BW (g) | 469.1±15.9 | 468.2±13.8 | 447.8±17.7 | 465.3±14.6 |
| LVW/BW (mg/g) | 2.01±0.04 | 2.01±0.10 | 2.33±0.10 †† | 2.21±0.08 |
| LiW/BW (mg/g) | 35.32±0.85 | 41.69±0.61 *** | 33.91±0.87 | 35.14±2.39 |
| GLU (mmol/l) | 10.32±0.73 | 13.8±0.79 * | 8.73±0.89 | 7.16±0.46 |
| CHOL (mmol/l) | 1.69±0.07 | 1.83±0.11 | 1.98±0.10 † | 2.25±0.30 |
| TRIGL (mmol/l) | 1.57±0.17 | 2.69±0.42 * | 1.34±0.29 | 2.15±0.36 |
Abbreviations: L-N – NG-nitro-L-arginine methyl ester (L-NAME), BP – blood pressure, HR – heart rate, BW – body weight, LVW/BW – left ventricular weight-to-body weight, LiW/BW – liver weight-to-body weight, GLU – glucose, CHOL – cholesterol, TRIGL – triglycerides. Values represent mean±SEM; n = 5–8;
*
p<0.05
***
p<0.001 Wistar vs. Wistar + fructose;
†
p<0.05
††
p<0.01
†††
p<0.001 Wistar vs. Wistar + L-N.