Table 3.
Inhibitors | Residues involved | |
---|---|---|
Hydrogen bond | Hydrophobic interaction | |
Nonpeptidyl | ||
Rosmarinic acid | ARG179, SER236, GlN283, ARG341, PHE381 | HIS237, CYS285, SER339, TRP340, and ARG341 |
Curcumin | ARG179, and SER343 | HIS237, GLN283, ALA284, TYR338, SER339, TRP340, ARG341, and PHE381 |
Luteolin | ARG179, SER236, GLN283, and TYR338 | HIS237, CYS285, TYR338, SER339, ARG341, and PHE381 |
Huperzine A | ARG179 | HIS237, CYS285, TYR338, SER339, TRP340, and ARG341 |
Peptidyl | ||
Tetrapeptide aldehyde AC-DEVD-CHO |
ARG179, SER236, GlN283, ARG341, SER343, and SER339 | HIS237, CYS285, TRP340, ARG341, and SER343 |
Bold and italic amino acids represent similar interaction as observed for peptidyl inhibitor.