Fig. 7.

Snapshots at atomic resolution of the UTP-bound catalytic site of two archaeo-eukaryotic primases.

Residues backbone and side-chains involved in the interaction between the UTP and the catalytic domain of the archaea (left) and human (right) primases are displayed with purple, red and blue sticks corresponding to C, O and N atoms respectively. Both UTP molecules are shown with green, red, blue, orange and white sticks for C, O, N, P and H atoms respectively. Cyan spheres represent water molecules and manganese atoms in P. horikoshii and H. sapiens respectively. Conserved aspartates are indicated in red and represented with sticks. Zinc atom is shown with orange spheres. Detailed contacts are described in the “Nucleotide binding” section.