Table 1.

Summary of the most important high-resolution structures mentioned in the analysis.

Protein	Organism	Associated metals	Cofactors	PDB ID	Comments	References
Primase	Plasmid pRN1 Sulfolobus islandicus	Zn		3M1M	Residues (res.) 36–370	[28]
Primase	Plasmid pRN1 Sulfolobus islandicus	Zn, Mn		1RO2	Triple mutant	[23]
Primase	Plasmid RSF1010		Single-stranded initiator DNA	3H25	Res. 1–212 27 nt DNA	[26]
Primase	Pyroccocus furiosus	Zn		1G71	Res. 1–344	[20]
Primase	Pyroccocus horikoshii	Zn	Uridine 5′-triphosphate	1 V34	Res. 1–346	[21]
Primase	Sulfolobus solfataricus	Zn		1ZT2	PriS: res. 1–330 PriL: res. 1–212	[22]
Primase	Saccharomyces cerevisiae	Zn, 4Fe		3LGB	PriL-CTD: res 316–512 Fe–S cluster	[34]
Primase	Homo sapiens	Zn, Mn	Uridine 5′-triphosphate	4LIL	p48: res. 1–390	[25]
Primase	Homo sapiens	Zn		4LIM	p48: res. 8–396	[25]
Primase	Homo sapiens	4Fe		3Q36	PriL res. 266–457 Fe–S cluster	[35]
Primase	Homo sapiens	Zn, Mg	Uridine 5′-triphosphate	4BPW	PriS: res. 1–420 PriL: res. 1–253	[12]
Primase	Homo sapiens	Zn		4RR2		[60]
Polymerase α	Saccharomyces cerevisiae		RNA primer DNA template	4FXD	Res. 349–1258 16 nt DNA 10 nt RNA	[24]
Polymerase α	Saccharomyces cerevisiae		2′-deoxyguanine 5′-triphosphate RNA primer DNA template	4FYD	Res. 349–1258 25 nt DNA 12 nt RNA triple mutant	[24]
Putative DNA ligase-like protein	Mycobacterium tuberculosis	Mn	Uridine 5′-triphosphate DNA	3PKY	PolDom res. 6–291 5 + 5 nt DNA	[40]
Cryptochrome DASH	Arabidopsis thaliana		FAD* MHF#	2VTB	Res. 44–569 5 nt DNA	[61]

We listed the protein type, the organism, the PDB codes and the corresponding references. In addition, we indicated the protein boundaries and the oligonucleotides length (if required) as well as the associated metals and cofactors. *FAD and ^#MHF are Flavin-Adenine Dinucleotide and 5,10-Methenyl-6,7,8-Trihydrofolic acid respectively. Empty squares in the “Associated metals” column indicate that no metal atoms are present in the PDB file.