Table 1. Novel CA II Inhibitors from Family 3 of Figure 2.

compd	Ri moiety	Ki (nM)
7	2-napththalenyl	2.6
8	3-isopropoxyphenyl	3.9
9	3-isopropylphenyl	0.3
10	3-chloro-4-fluorophenyl	2.7
11	3-chloro-4-methylphenyl	0.77