Table 1. Cytotoxicity of Is-BetA and Other Derivatives in Cancer (MCF-7, B16-F10, OVCAR 3, MDA-MB-231, PANC-1, and A549) and Noncancer Cells (CHO, NIH3T3) Following 72 h of Continuous Treatment (ND, Not Determined).
| MCF7 (IC50, μM) | B16-F10 (IC50, μM) | OVCAR 3 (IC50, μM) | MDA-MB-231 (IC50, μM) | PANC1 (IC50, μM) | A549 (IC50, μM) | CHO (IC50, μM) | NIH 3T3 (IC50, μM) | |
|---|---|---|---|---|---|---|---|---|
| Is-BetA | 7.396 ± 0.034 | 2.296 ± 0.037 | 6.048 ± 0.018 | 1.256 ± 0.004 | 2.630 ± 0.032 | 2.560 ± 0.022 | >20 | >20 |
| BetA | 10.527 ± 0.024 | >20 | 8.366 ± 0.008 | >20 | 10.223 ± 0.022 | >20 | >20 | >20 |
| BetA-FITC | ND | 20 | ND | ND | 9.778 ± 0.033 | ND | ND | >20 |
| Is-amine | ND | >20 | ND | >20 | >20 | 1.359 ± 0.004 | ND | ND |
| Is-PMB | >20 | >20 | >20 | >20 | >20 | ND | >20 | >20 |
| Dox | ND | 0.663 ± 0.024 | ND | ND | 1.026 ± 0.036 | ND | ND | 7.211 ± 0.029 |