Table 2. Summary of Rat PK for EPZ011989.
| EPZ011989
Rat PK | ||||||
|---|---|---|---|---|---|---|
| dose (mg/kg) |
route |
t1/2 (h) |
tmax (h) |
Cmax (ng/mL) |
AUCinf (h·ng/mL) |
time above LCC (h) |
| 30 | p.o. | 4.7 | 2 | 240 | 970 | 4 |
| 100 | p.o. | 3.9 | 2.7 | 1600 | 5600 | 8 |
| 300 | p.o. | 3.7 | 2.7 | 2900 | 10000 | 10 |
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