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. 2015 Mar 22;6(5):537–542. doi: 10.1021/acsmedchemlett.5b00026

Scheme 4. Synthesis of Monocarbams with 4-Substituted β-Lactams.

Scheme 4

(a) (i) 14a or 14b, MSTFA, THF; (ii) 6b, CSI, DCM, 0 °C; (iii) THF, 0 °C − rt; (b) Pd black, H2, EtOH; (c) TFA, DCM 0 °C; (d) BCl3, DCM; (e) (i) Pd black, H2 (1 atm), THF; (ii) MSTFA, THF; (f) (i) 5, CSI, DCM, 0 °C; (ii) THF, 0 °C − rt.