Table 3. Intravenous Rat PK of Selected Monocarbamsa.
| compd |
|||||
|---|---|---|---|---|---|
| 7a | 7b | 10a | 24c | 24d | |
| rat CL (mL min–1 kg–1) | 8.9 | 7.3 | 9.5 | 11 | 12 |
| t1/2 (h) | 2.5 | 3.0 | 2.0 | 2.0 | 2.0 |
| Vss (L/kg) | 0.23 | 0.21 | 0.26 | 0.18 | 0.35 |
a
Han Wistar rat (male), 1 mg/kg, n = 2.
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