Table 2. Effect of Benzimidazole N-Substitution on Rat Pharmacokinetic Profile^a.

compd	PPBb	Mic Clintc	F (%)d	AUCN (po)e	Clpf
1	25	30	37	0.56	59
5	15	28	77	1.82	28
6	19	82	32	0.20	131

^aAssay details reported in Supporting Information.

^bProtein binding in rat plasma, reported as % free compound.

^cIntrinsic clearance in rat liver microsomes (mL/min/kg).

^dBioavailability.

^eArea under the curve, normalized for dose (μM·h·kg/mg).

^fPlasma clearance (mL/min/kg).