Table 5. Activity of Selected Compounds at Related CYP Enzyme Targets.
compd | CYP17a (IC50, nM) | CYP19a (IC50, nM) | CYP21a (IC50, nM) | CYP3A4a (IC50, nM) |
---|---|---|---|---|
26 | >10000 | 4513 | >10000 | >50000 |
31 | >10000 | 1268 | >10000 | >50000 |
32 | >10000 | 1021 | >10000 | >50000 |
35 | >10000 | n.d. | >10000 | 8235 |
Assay details reported in Supporting Information.