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. 2015 Apr 7;6(5):573–578. doi: 10.1021/acsmedchemlett.5b00054

Table 5. Activity of Selected Compounds at Related CYP Enzyme Targets.

compd CYP17a (IC50, nM) CYP19a (IC50, nM) CYP21a (IC50, nM) CYP3A4a (IC50, nM)
26 >10000 4513 >10000 >50000
31 >10000 1268 >10000 >50000
32 >10000 1021 >10000 >50000
35 >10000 n.d. >10000 8235
a

Assay details reported in Supporting Information.