Table 2. MCT1 IC₅₀ Values of o-Methoxy p-N,N-Dialkyl/Aryl Cyanocinnamic Acids.

Sl. No.	X	Y	% yielda	MCT1 IC50 (nM)c
22	N,N-dipropyl	H	62	12 ± 1
23	N,N-dibutyl	H	60	9 ± 1
24	N,N-diisobutyl	H	58	11 ± 4
25	N,N-dipentyl	H	74	34 ± 7
26	N,N-diphenyl	H	66	8 ± 1
27	N,N-diphenyl	Na	78b	11 ± 3
28	N,N-diallyl	H	70	29 ± 2
29	pyrrolidinyl	H	68	48 ± 20
30	piperidinyl	H	85	25 ± 5

^aStarting from aldehydes.

^bStarting from acid.

^cAverage IC₅₀ values of minimum three separate experiments. Values reported as avg ± SEM.