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Compound 22e inhibits tumor growth in EBC-1 xenografts. Compound 22e in the methanesulfonic acid salt form or JNJ38877605 was administered orally once daily for 3 weeks after the tumor volume reached 100 to 150 mm3. The results are expressed as the mean ± SEM (drug-treated group, n = 6; vehicle group, n = 12). *p < 0.05, ***p < 0.001 vs control group, determined using Student’s t test.
