Table 1. SAR of Substituents on the Imidazo[1,2-a]pyridine Scaffold.

^aIC₅₀ values were calculated by the Logit method from the results of at least two independent tests with eight concentrations each and expressed as mean ± SD; c-Met IC₅₀ of Crizotinib = 2.4 ± 0.1 nM; c-Met IC₅₀ of JNJ38877605 = 1.8 ± 0.3 nM.

^bEBC-1: human nonsmall-cell lung cancer cell line that expresses elevated levels of constitutively active c-Met.

^cNot detected.