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. 2015 Mar 2;6(5):507–512. doi: 10.1021/ml5004876

Table 3. SAR of Substituents on the Amides.

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a

IC50 values were calculated by the Logit method from the results of at least two independent tests with eight concentrations each and expressed as mean ± SD; c-Met IC50 of Crizotinib = 2.4 ± 0.1 nM; c-Met IC50 of JNJ38877605 = 1.8 ± 0.3 nM.

b

EBC-1: human nonsmall-cell lung cancer cell line that expresses elevated levels of constitutively active c-Met.