Table 2. In Vivo Rat PK Properties after Dosing of 3 mg/kg IV and 10 mg/kg PO.

rat PKa	15b	16b	17c
CL (mL/min/kg)	56.9	45.5	45.2
Vss (L/kg)	2.3	2.4	4.9
T1/2 (h)	0.83	0.9	1.6
AUC PO (h·nM)	659	1897	1879
Cmax PO (nM)	110	250	215
F(%) PO	10	26	27

^aRoute: Intravenous (3 mg/kg) and oral administrations (10 mg/kg). Formulation as a solution in 75% PEG300/25% D5W.

^bMale Sprague–Dawley rat.

^cMale Wistar rat.