Table 3. Ba/F3 Cellular Kinase Panel (IC50, μM).
| Ba/F3a | 1 | 14 | 16 | 17 |
|---|---|---|---|---|
| ABLb | 3.8 | NA | 2.4 | 5.2 |
| ALKc | 4.8 | 6.3 | 1.2 | 3.0 |
| ALK | 3.1 | NA | 2.2 | 3.9 |
| BRAF | 2.5 | NA | 6.2 | 5.9 |
| BMX | 9.7 | >10 | 2.7 | 4.3 |
| FGFR3 | 3.9 | 9.5 | 4.9 | 5.0 |
| FGFR4 | 5.9 | 9.2 | 5.3 | 4.4 |
| FGR | 6.4 | 8.7 | 2.8 | 5.9 |
| FLT1 | 3.0 | NA | 2.6 | 5.3 |
| FLT3 | 0.72 | 8.1 | 3.3 | 4.3 |
| FMS | 3.4 | >10 | 2.5 | 5.3 |
| IGF1R | 4.0 | NA | 5.1 | 5.4 |
| INSR | 8.6 | 8.8 | 5.3 | 6.0 |
| JAK2 | 4.7 | 6.7 | 2.7 | 5.6 |
| KDR | 4.1 | 6.5 | 1.0 | 5.0 |
| KIT | 2.2 | 5.5 | 0.79 | 7.0 |
| LCK | 2.0 | NA | 3.0 | 5.2 |
| LYN | 7.5 | 6.4 | 3.4 | 4.9 |
| MER | 5.4 | NA | 4.7 | 5.1 |
| MET | 5.1 | 7.7 | 4.3 | 5.7 |
| PDGFRβ | 2.0 | NA | 2.2 | 4.6 |
| RET | 4.9 | 8.0 | 3.7 | 6.0 |
| RON | 6.1 | NA | 5.0 | 4.8 |
| ROS | 0.30 | 0.6 | 0.06 | 0.21 |
| SRC | 4.6 | NA | 2.5 | 4.6 |
| SYK | 4.0 | NA | 4.4 | 7.9 |
| TIE1 | 5.5 | 6.5 | 4.3 | 5.5 |
| TYRO3 | NA | NA | 5.2 | 5.0 |
| ZAP70 | 6.4 | NA | 5.2 | 5.5 |
a
Ba/F3 cells rendered IL-3 independent by stable transduction with the indicated kinase fused with a Tel dimerization partner unless otherwise specified.
b
BCR-ABL.
c
NMP-ALK.