Table 2.
Evolution of imiglucerase dose during the supply constraint period
| Dose of imiglucerase (U/kg/4-weeks) | Change from pre-constraint dose (U/kg/4-weeks) | ||||||
|---|---|---|---|---|---|---|---|
| n | Mean (SD) | Median (range) | n | Mean (SD) | Median (range) | ||
| Pre-constraint (in the 6 months prior to first modification) | 94 | 92.5 (33.5) | 92 (10; 239) | ||||
| First modification on or after 01 Jun 2009 | 99 | 35.0 (32.0) | 40 (0; 181) | 94 | −55.9 (28.9) | −52 (−127; −6) | |
| Time interval after the first modification: | 3 months | 98 | 17.5 (29.4) | 0 (0; 160) | 93 | −74.1 (38.6) | −69 (−223; 0) |
| 6 months | 95 | 41.0 (42.8) | 49 (0; 160) | 91 | −51.1 (51.6) | −51 (−223; 62) | |
| 9 months | 95 | 55.9 (45.0) | 56 (0; 170) | 90 | −36.6 (48.1) | −29 (−223; 62) | |
| 12 months | 96 | 37.3 (45.5) | 0 (0; 129) | 91 | −55.8 (52.2) | −60 (−223; 62) | |
| Last modification prior to 01 Nov 2010 | 98 | 37.6 (47.3) | 0 (0; 160) | 93 | −56.2 (49.7) | −64 (−130; 62) | |
n: number of patients with available data; SD: standard deviation; Range: minimum; maximum.