Table 3.
Comparison of EC50 values (μM) of DT320 vs conventional agents on different cancer cell lines
| Cell Line | DT320 | DT320 | Conventional agent | Conventional agent |
|---|---|---|---|---|
| SISgel | Monolayer | SISgel | Monolayer | |
| MDA-MB-231 (breast) | 8.7 ± 1.1 | 78.1 ± 7.1 | 47.8 ± 4.0 (D) | 45.4 ± 1.9 (D) |
| PC-3 (prostate) | 19.7 ± 2.0 | 41.5 ± 4.1 | 102.2 ± 7.0 (D) | 104.1 ± 6.1 (D) |
| J82 (bladder) | 30.9 ± 4.8 | 71.2 ± 8.1 | >300 (C) | 102.3 ± 10.2 (C) |
| Capan-1 (pancreatic) | 22.9 ± 4.8 | 80.1 ± 10.2 | 83.1 ± 10.7 (G) | 78.2 ± 9.8 (G) |
Data represent n = 6-8 from three separate experiments. D = doxorubicin, G = gemcitabine, C = cisplatin